殷文博  理學博士  副研究員  碩士生導師

郵箱：yinwb@hainanu.edu.cn

1.教育背景與工作經曆

2025．01至今 海南大學 365英国上市官网在线 副研究員

2022．09—2024．12 北京大學 藥物化學生物學 博士後

2019．09—2022．06 沈陽藥科大學 藥物化學 博士學位

2016．09—2019．06 沈陽藥科大學 藥物化學 碩士學位

2012．09—2016．06 大連醫科大學 生物制藥 學士學位

2.科研情況

聚焦于肺部疾病與感染性疾病，采用計算機輔助藥物設計、基于靶點的藥物設計等方法進行藥物開發與相關機制研究。近5年在J. Med. Chem, Eur J Med Chem等期刊發表SCI論文20餘篇；主持國自然青年基金一項、參與國自然面上項目一項；完成上海醫藥集團橫向一項（251萬元），所設計并合成分子A17現已與上海濟煜醫藥科技有限公司達成合作。

3.研究領域：藥物化學與化學生物學

新型PDE抑制劑的開發；

抗耐藥感染藥物開發與機制研究；

新型偶聯藥物與降解劑開發；

4.社會兼職

Eur J Med Chem等藥物化學雜志審稿人；中國化學會會員。

5.代表性項目

1) 國家自然科學基金青年項目，82304278，20萬元，主持；

2）國家自然科學基金面上項目，81872729，57萬元，參與；

6.代表性成果

1）Yin, W. B.; Wu, T. X.; Liu, L.; Jiang, H.; Zhang, Y. X.; Cui, H. X.; Sun, Y.; Qin, Q. H.; Sun, Y. X.; Gao, Z. X.; Zhao, L. Y.; Su, X.; Zhao, D. M*.; Cheng, M. S. Species-selective Targeting of Fungal Hsp90: Design, Synthesis, and Evaluation of Novel 4,5-diarylisoxazole Derivatives for the Combination Treatment of Azole-Resistant Candidiasis. J. Med. Chem. 2022, 65, 5539-5564.

2）Yin, W. B.; Liu, L.; Jiang, H.; Wu, T. X., Cui, H. X.; Zhang, Y. X.; Gao, Z. Y.; Sun, Y.; Qin, Q. H.; Zhao, L. Y.; Su, X.; Zhao, D. M*.; Cheng, M. S. Design, synthesis, and evaluation of novel 3-thiophene derivatives as potent antifungal and fungistatic reagents based on a conformational restriction strategy. Eur. J. Med. Chem. 2022, 233, 114195.

3）Yin, W. B.; Cui, H. X.; Jiang, H.; Zhang, Y. X.; Liu, L.; Wu, T. X.; Sun, Y.; Zhao, L. Y.; Su, X.; Zhao, D. M*.; Cheng, M. S. Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents. Eur. J. Med. Chem. 2022, 227, 113955.

4）Yin, W. B.; Zhang, Y. X.; Cui, H. X.; Jiang, H.; Liu, L.; Zheng, Y.; Wu, T. X.; Zhao, L. Y.; Sun, Y.; Su, X.; Li, S.; Zhao, D. M*.; Cheng, M. S. Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi. Eur. J. Med. Chem. 2021, 225, 113740.

5） Zhao, L. Y.; Yin, W. B.; Sun, Y.; Sun, N. N.; Tian, L. F.; Zheng, Y.; Zhang, C.; Zhao, S. Z.; Su, X.; Zhao, D. M*.; Cheng, M. S. Improving the metabolic stability of antifungal compounds based on a scaffold hopping strategy: Design, synthesis, and structure-activity relationship studies of dihydrooxazole derivatives. Eur. J. Med. Chem. 2021, 224, 113715.

6）Zhao, L. Y.; Sun, Y.; Yin, W. B.; Tian, L. F.; Sun, N. N.; Zheng, Y.; Zhang, C.; Zhao, S. Z.; Su, X.; Zhao, D. M*.; Cheng, M. S. Design, synthesis, and biological activity evaluation of 2-(benzo[b]thiophen-2-yl)-4-phenyl-4,5-dihydrooxazole derivatives as broad-spectrum antifungal agents. Eur. J. Med. Chem. 2021, 228, 113987.

7）Guo, J.; Zhao, F.; Yin, W. B.; Zhu, M. Y.; Hao, C. Z.; Pang, Y.; Wu, T. X.; Wang, J.; Zhao, D. M*.; Li, H. T*.; Cheng, M. S*. Design, synthesis, structure-activity relationships study and X-ray crystallography of 3-substituted-indolin-2-one-5-carboxamide derivatives as PAK4 inhibitors. Eur. J. Med. Chem. 2018, 155,197-209.

8）Qin, Q. H.; Wu, T. X.; Yin, W. B.; Sun, Y. X.; Zhang, X. Y.; Wang, R. F.; Guo, J.; Zhao, D. M*.; Cheng, M. S. Discovery of 2,4-diaminopyrimidine derivatives targeting p21-activated kinase 4: Biological evaluation and docking studies. Archiv der Pharmazie. 2020, 353(10), 2000097.

歡迎具有藥學、化學、生物學背景的同學報考本課題組研究生。