劉進  博士  副研究員  博士生研究生導師

  郵箱：jin_liu@hainanu.edu.cn

  1.教育背景

  2019.09—2022.06，南方醫科大學， 藥物化學，醫學博士；

  2014.09—2017.06，沈陽藥科大學， 藥物化學，理學碩士；

  2009.09—2013.06，吉林醫365英国上市官网在线，     藥學，理學學士；

  2.教學情況

  藥物分子設計、學術道德規範、藥品生産質量管理工程

3.科研情況

  緻力于創新小分子藥物的研究，在藥物設計、合成以及生物評價方面積累了豐富的經驗。近年來圍繞抗代謝性疾病藥物、腫瘤免疫小分子藥物和靶向蛋白降解的抗炎藥物等研究領域開展了一系列基礎與應用研究。近三年科研成果突出，已在J. Med. Chem, Eur J Med Chem等期刊發表SCI論文20餘篇，申請專利6項，主持科研項目5項。

  4.研究領域

抗腫瘤藥物；

抗代謝性疾病藥物；

靶向蛋白降解抗炎藥物

5.代表性項目

（1）國家自然科學基金青年項目，30萬，主持

（2）海南省自然科學基金面上項目，8萬，主持

（3）365英国上市官网在线2024年本科生課外科研課題，主持

（4）365英国上市官网在线2023年本科生課外科研課題，主持

（5）海南省2023年研究生創新科研項目，主持

（6）中組部青年海外高層次人才項目，300萬，參與。

（7）廣東省科技廳國際合作項目，50萬，參與并結題。

（8）國家自然科學基金面上項目，55萬，參與。

6.代表性成果

(1) Rui Gao^#, Weixin Wang^#, Zhongchao Wang^#, Yapeng Fan, Lin Zhang, Jiahui Sun, Miaofang Hong, Min Pan, Jianming Wu, Qibing Mei, Yini Wang, Lingyan Qiao, Jin Liu*, Fei Tong*. Hibernating/Awakening Nanomotors Promote Highly Efficient Cryopreservation by Limiting Ice Crystals. Adv Healthc Mater. 2024 Dec;13(30). (中科院一區, IF:11.3)

(2) Ziyang Li#, Can Mao#, Yixin Zhao, Yanbin Zhao, Hanyu Yi, Jin Liu*, Jinqiang Liang* The STING antagonist SN-011 ameliorates cisplatin induced acute kidney injury via suppression of STING/NF-κB-mediated inflammation. Int Immunopharmacol. 2024 Dec 21:146:113876. (中科院二區, IF:4.8)

(3) Weixin Wang^#, Renquan Fu^#, Rui Gao^#, Lei Luo, Zhongchao Wang, Yingli Xue, Jiahui Sun, Min Pan, Miaofang Hong, Lingyan Qiao, Weiwei Qiao, Qibing Mei, Jianming Wu, Yini Wang, Yali Zhong, Jin Liu*, Fei Tong*. H₂S-Powered Nanomotors for Active Therapy of Tumors by Inducing Ferroptosis and Lactate-Pyruvate Axis Disorders. ACS Biomater Sci Eng. 2024 Jun 10;10(6):3994-4008. (中科院二區, IF:5.5)

(4) Jin Liu*^,#, Yao Cheng^#, Lin Yuan^#, Ting Liu^#, Yong Ruan, Yichang Ren, Ling Li, Sheng Jiang*, Yibei Xiao*, Jianjun Chen*; Discovery and Crystallography Study of Novel Biphenyl Ether and Oxadiazole Thioether (Non-Arylmethylamine)-Based Small-Molecule PD-1/PD-L1 Inhibitors as Immunotherapeutic Agents. J. Med. Chem. 2023 Sep 28;66(18):13172-13188. (中科院一區TOP, IF:7.3)

(5) Yichang Ren^#, Yuxi Wang^#, Jin Liu^#, Ting Liu, Lin Yuan, Chengyong Wu, Zichao Yang, Jianjun Chen; X-ray Crystal Structure-Guided Discovery of Novel Indole Analogues as Colchicine-Binding Site Tubulin Inhibitors with Immune-Potentiating and Antitumor Effects against Melanoma. J. Med. Chem. 2023 May 25;66(10):6697-6714. (中科院一區TOP, IF:7.3)

(6) Fei Tong^#, Jin Liu^#, Yali Zhong, Yingli Xue, Lei Luo, Zhongchao Wang, Lingyan Qiao, Xiuzhi Zhou, Weixin Wang, Jiahui Sun, Miaofang Hong, Jianming Wu, Qibing Mei, Guosheng Wu; Carbon monoxide-propelled nanomotors as an active treatment for renal injury. Applied Materials Today, 32 (2023) 101823. (中科院二區, IF:8.3)

(7) Fei Tong^#, Jin Liu^#, Lei Luo, Lingyan Qiao, Jianming Wu, Guosheng Wu, Qibing Mei; pH/ROS-responsive propelled nanomotors for the active treatment of renal injury. Nanoscale. 2023 Apr 6;15(14):6745-6758. (中科院二區TOP, IF:8.3)

(8) Jin Liu, Yong Ruan, Bulian Deng, Lin Yuan, Yichang Ren, Ling Li, Zicao Yang, Ting Liu, Huiting Zhao, Ruiyao Mai, Jianjun Chen*; Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J. Med. Chem. 2022 May 12;65(9):6593-6611 (中科院一區TOP, IF:7.3)

(9) Zean Zhao^#, Jin Liu^#, Lin Yuan, Zichao Yang, Peihua Kuang, Hui Liao, Jian Luo, Huancun Feng, Fengxin Zheng, Yongjun Chen, Ting Wu, Jiayin Guo, Ying Cao, Yang Yang, Cuiting Lin, Qun Zhang*, Jianjun Chen*, Jianxin Pang*; Discovery of novel benzbromarone analogs with improved pharmacokinetics and benign toxicity profiles as antihyperuricemic agents. Eur J Med Chem. 2022 Agu 18; 242:114682. (中科院一區TOP, IF:6.7)

(10) Zean Zhao^#, Jin Liu^#, Peihua Kuang, Jian Luo, Goverdhan Surineni, Xiaolin Cen, Ting Wu, Ying Cao, Pingzheng Zhou, Jianxin Pang, Qun Zhang, Jianjun Chen^*; ¹Eur J Med Chem. 2022 Feb 5; 229:114092. (中科院一區TOP, IF:6.7)

(11) Ling Li^#, Jin Liu^#, Huiting Zhao, Bulian Deng, Zichao Yang, Yichang Ren,Ruiyao Mai, Junli Huang, Jianjun Chen*; ²Eur J Med Chem. 2022 March 3; 233: 114243 (中科院一區TOP, IF:6.7)

(12) Yuanxing Zhi^#, Jin Liu^#, Peihua Kuang, Xin Zhang, Ziwei Xu, Pingzheng Zhou*, Jianjun Chen*. Novel DCPIB analogs as dual inhibitors of VRAC/TREK1 channels reduced cGAS-STING mediated interferon responses. Biochem Pharmacol. 2022 March 10; 199: 114988 (中科院二區TOP, IF:5.8)

(13) Jin Liu, Daiying Zuo, Tongfei Jing, Ming Guo, Lingyun Xing, Wenyu Zhang, Jianwen Zhao, Jiwei Shen, Ping Gong, Dajun Zhang, Xin Zhai*. Optimization and biological evaluation of novel 5,7-diarylimidazo [1,2-a] pyridine-8-carbonitriles as potent antitubulin agents. Bioorg. Med. Chem. 2017,25(15):4088-4099 (IF:3.461)

7.著作專利

(1) 劉進，吳迪等，DPP-Ⅳ抑制劑特力利汀的合成工藝改進[J]. 中國藥物化學雜志

(2) 陳建軍，劉進。一種富馬酸酰胺類化合物或其藥學上可接受的鹽及其制備方法和應用。CN114085215B

(3) 龐建新，陳建軍，趙澤安，劉進，吳婷，田元新。雜環芳酰胺類化合物及其制備方法和應用CN115160314B

(4) 陳建軍，彭孝鵬，李玲，任益昌，劉進。一種N-羰基-9,10-二氫吖啶類化合物及其應用。CN111018780A

(5) 龐建新，陳建軍，田元新，吳婷，趙澤安，邝沛華，劉進，李璐，李詠梅。一種吡啶3-胺衍生物及其制備方法和應用。CN113979931A

歡迎具有藥學、化學、生物學背景的同學報考本課題組研究生。