宋施豪  男 博士 副研究員 博（碩）士生導師

  電子郵箱：songsh@hainanu.edu.cn

  1.教育背景

  2018.6–2020.6:南洋理工大學，理學院，博士聯合培養  

  2018.9–2021.6: 華南農業大學，植物保護學院，博士  

  2021.6–2022.9: 中山大學，365英国上市官网在线（深圳），博士後  

  2022.9–至今: 海南大學，365英国上市官网在线，副研究員

  2.科研情況

  主持國家自然科學基金青年基金、博士後面上項目和高校基本科研業務費項目，作為科研骨幹參與一項國家重點研發計劃。以第一作者或通訊作者在國際高水平SCI期刊如Nature Communications, PLOS Pathogens，CCS Chemistry，ISME Journal，Virulence，Molecular Plant Pathology等發表論文13篇（中科院一區7篇），同時已授權國家發明專利16項。

  3.研究領域

病原細菌信号調控與緻病機理

病原細菌-宿主互作機制研究

新型抗菌藥物研制及作用機理研究

4.代表性項目

1）國家自然科學基金青年項目，金額30萬，主持，2024年，在研。

2）博士後面上項目，金額：8萬，主持，2022年，結題。

3）中央高校基本科研業務費，金額：5萬，主持，2022年，結題。

4）國家重點研發專項“變革性技術關鍵科學問題”—高通量培養篩選鑒定健康相關微生物的關鍵技術，金額：2374萬，課題骨幹，2021年，在研。

5.代表性成果

1) Xu Y^#, Song S^#, Duan H, Deng Y*, Liu XW*. (2024). Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan: Antibody Recruiting at Engineered Bacterial Surface with Peptidoglycan Analogs. CCS Chemistry, 6:1-10. (IF: 11.2, 中科院1區)

2) Li X^#, Yin W^#, Lin JD^#, Zhang Y, Guo Q, Wang G, Chen X, Cui B, Wang M, Chen M, Li P, He YW, Qian W, Luo H, Zhang LH, Liu XW*, Song S*, Deng Y*. (2023). Regulation of the physiology and virulence of Ralstonia solanacearum by the second messenger 2',3'-cyclic guanosine monophosphate. Nature Communications 14(1):7654. (IF: 16.6, 中科院1區)

3) Song S^#,*, Zhao S^#, Sun X^#, Meng L, Wang Z, Tan H, Liu J, Zhang M, Deng Y*. (2023). Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection. Virulence 14(1):2265012. (IF = 5.2, 中科院1區)

4) Huang J^#, Song S^#,*, Zhao S, Sun X, Wang Z, Huang X, Xiao Q, Deng Y*. (2023). Anti-virulence activity of novel (1-heteroaryloxy-2-hydroxypropyl)-phenylpiperazine derivatives against both wild-type and clinical drug-resistant Candida albicans strains. Microbial Biotechnology 16(1):116-127. (IF:5.7, 中科院2區)

5) Song S, Sun X, Guo Q, Cui B, Zhu Y , Li X, Zhou J, Zhang LH, Deng Y*. (2022). An anthranilic acid-responsive transcriptional regulator controls the physiology and pathogenicity of Ralstonia solanacearum. PLoS Pathogens 18(5): e1010562. (IF:6.7, 中科院1區)

6) Ye P^#, Li X^#, Cui B^#, Song S^#, Shen F, Chen X, Wang G, Zhou X, Deng Y*. (2022). Proline utilization A controls bacterial pathogenicity by sensing its substrate and cofactors. Communications Biology 5:496. (IF: 5.9, 中科院1區)

7) Wang M^#, Li X^#, Song S^#, Cui C, Zhang LH, Deng Y*. (2022). The cis-2-dodecenoic acid (BDSF) quorum sensing system in Burkholderia cenocepacia. Applied and Environmental Microbiology 88(4):e0234221. (IF: 4.4, 中科院2區)

8) Song S^#, Sun X^#, Meng L, Wu Q, Wang K, and Deng Y*. (2021) Antifungal activity of hypocrellin compounds and their synergistic effects with antimicrobial agents against Candida albicans. Microbial Biotechnology 14(2):430-443. (IF: 5.7, 中科院2區, Highlight by Microbial Biotechnology 2020, 13, 1702-1704)

9) Song S^#, Yin W^#, Sun X, Cui B, Huang L, Li P, Yang L, Zhou J, Deng Y*. (2020) Anthranilic acid from Ralstonia solanacearum plays dual roles in intraspecies signalling and inter-kingdom communication. ISME Journal 14:2248-2260. (IF: 11.0, 中科院1區)

10) Shen F^#, Yin W^#, Song S^#, Zhang Z, Ye P, Zhang Y, Zhou J, He F*, Li P*, and Deng Y*. (2020) Ralstonia solanacearum promotes pathogenicity by utilizing L-glutamic acid from host plants. Molecular Plant Pathology 21:1099-1110. (IF: 4.9, 中科院1區)

11) Cui C^#, Song S^#, Yang C^#, Sun X, Huang Y, Li K, Zhao S, Zhang Y, and Deng Y*. (2019) Disruption of Quorum Sensing and Virulence in Burkholderia cenocepacia by a Structural Analogue of the cis-2-Dodecenoic Acid Signal. Applied and Environmental Microbiology 85(8):e00105-19. (IF: 4.6, 中科院2區)

12) Song S^#, Fu S^#, Sun X^#, Li P, Wu J, Dong T, He F and Deng Y*. (2018) Identification of Cyclic Dipeptides from Escherichia coli as New Antimicrobial Agents against Ralstonia solanacearum. Molecules 23(1):214. (IF: 4.6, 中科院2區)

13) Cui C^#, Yang C^#, Song S^#, Fu S, Sun X, Yang L, He F, Zhang LH, Zhang Y, and Deng Y*. (2018) A novel two-component system modulates quorum sensing and pathogenicity in Burkholderia cenocepacia. Molecular Microbiology 108: 32-44. (IF: 3.6, 中科院2區)

6.榮譽獎勵

深圳市海外高層次C類人才

海南省高層次人才