王  陽  理學博士  副研究員 博士生導師 郵箱：wang-yang@hainanu.edu.cn

1.教育背景      

2017.09 - 2021.06 理學博士  有機化學  中山大學

2014.09 - 2017.06 理學碩士  材料化學  福建師範大學 （中科院福建物質結構所聯合培養）  

2010.09 - 2014.06 理學學士  材料化學  安陽師範學院  

2.工作經曆

2021.8-2024.01  博士後  香港中文大學（深圳）- 附屬第二醫院（深圳大學聯合招聘）

2024.03-至今   海南大學  365英国上市官网在线  副研究員

3.科研情況

基于化學修飾核酸或者核酸的動态結構實現光、小分子和蛋白質等條件響應控制核酸功能，特别是細胞内精準調控基因表達。目前以第一作者（共同第一作者）在Angew. Chem. Int. Ed., Sci. China Chem., CCS Chem., Chem. Sci., Chin. Chem. Lett., Chem. Commun.等化學雜志發表多篇論文。

4.研究領域

緻力于開發和應用化學工具研究和調控核酸的結構與功能，以化學手段精準控制功能核酸在細胞中發揮作用。

5.代表性項目

國家自然科學基金青年項目，22307107, 基于化學修飾核酸實現光正交策略多重控制表達，2024-01-01至2026-12-31，30萬元，主持。

6.代表性成果（#共同一作）

1) Yang Wang, Qiu-Long Zhang, Yan Liu, Liang-Liang Wang, Wu, Chao-Qun Wu, Ming Shao, Juan Du*, Xiwen Xing* and Liang Xu*. Photo-controllable Multiple and Orthogonal Regulation of Gene Expression by Chemically Modified Oligonucleotides. Sci. China Chem. 2024, 68, 694-704. (IF:10.4).

2)Yang Wang, Chao-Qun Wu, Qiu-Long Zhang, Ming Shao, Yan Liu, Liang-Liang Wang, Zun-Yun Wang, Juan Du*, and Liang Xu*. Switching On/Off of Guide RNA by Photo-Induced Strand Displacement for Functional Control of CRISPR/Cas9. CCS Chem. 2024. 6, 1338-1351. (IF:11.2).

3)Yang Wang, Yan Liu, Fan Xie, Jiao Lin and Liang Xu*, Photocontrol of CRISPR/Cas9 function by sitespecific chemical modification of guide RNA, Chemical Science, 2020. (IF:9.6)

4)Yan Liu^#, Yang Wang^#, Jiayi Zhu, Xuxian Su, Xudong Lin, Liang Xu* and Xiwen Xing*. Employing pH-responsive RNA triplex to control CRISPR/Cas9-mediated gene manipulation in mammalian cells. Chin. Chem. Lett, 2023. (IF:9.1)

5)Qiu-Long Zhang#, Yang Wang#, Liang-Liang Wang#, Fan Xie, Ruo-Yue Wu, Xu-Yang Ma, Han Li, Yan Liu, Shunchun Yao and Liang Xu*. Programming non-nucleic acid molecules into computational nucleic acid systems. Angew. Chem. Int. Ed. 2022. (IF:16.8)

6)Yan Liu#, Yang Wang#, Jiao Lin and Liang Xu*, Theophylline-induced synergic activation of guide RNA to control CRISPR/Cas9 function, Chemmical Communications, 2021. (IF:6.0)

7)Yang Wang, Yan Liu, Liang-Liang Wang, Qiu-Long Zhang*, and Liang Xu* Integrating ligands into nucleic acid systems. ChemBioChem, 2023. (IF:3.2)

8)Yang Wang, Xiaofeng Zhang, Haixiong Liu, Hui Chen and Deguang Huang*. Nickel-Catalyzed Direct Formation of C-S Bond of Aryl Sulfides from Arylsulfonyl Chlorides and Aryl Iodides Using Mn as a Reducing Agent. Org. Chem. Front. 2017. (IF:5.4)

9)Yang Wang#, Haixiong Liu#, Xiaofeng Zhang, Zilong Zhang and Deguang Huang*. Experimental and mechanistic insights into copper (II)-dioxygen catalyzed oxidative N-dealkylation of N-(2-pyridylmethyl) phenylamine and its derivatives. Org. Biomol. Chem. 2017, 15, 9164. (IF:3.6)