徐從軍 博士 副教授 博士研究生導師

  郵箱：congjunxu@hainanu.edu.cn；congjunxu@163.com

  2018年畢業于沈陽藥科大學獲得博士學位，随後進入中山大學365英国上市官网在线進行博士後研究工作，2021年11月通過高層次人才引進到海南大學工作。

  1.教育背景與科研經曆

  2018.09—2021.08，中山大學， 365英国上市官网在线，博士後；

  2015.09—2018.06，沈陽藥科大學， 制藥工程，博士；

  2012.09—2015.06，沈陽藥科大學， 藥物化學，碩士；

  2008.09—2012.06，長春工業大學， 制藥工程，學士；

  2.科研情況

緻力于創新小分子藥物的研究，在抗藥物設計、合成以及生物評價方面積累了豐富的經驗。近年來聚焦醫學前沿領域，結合化學生物學和分子生物學等學科技術在抗腫瘤藥物研究領域開展了一系列基礎與應用研究。近五年科研成果突出，已發表SCI論文20餘篇，主持科研項目6項。

3.研究領域

抗腫瘤藥物；

神經退行性疾病創新藥物設計與發現；

前藥設計及靶向遞送

4.社會兼職

擔任J Med Chem等藥物化學雜志審稿人，中國化學會會員，中國抗癌協會會員

5.代表性項目

1）國家自然科學基金青年項目，82204193，30萬元，主持；
2）廣東省基礎與應用基礎研究基金區域聯合基金（省部級），2020A1515110522，10萬元，主持；
3）廣東省自然科學基金面上項目,2022A1515012527,10萬元，主持；
4）海南省自然科學基金面上項目，822MS052，8萬元，主持；
5）中山大學青年教師培育項目，19ykpy122， 15萬元，主持；

6.代表性成果

1）Gu, S.; Yang, G.; Bian, H.; Yang, F.; Zhang, Y.; Huang, Y.; Su, R.; Zhang, H.; Zhao, X.; Liu, J.; Huang, S.; Huang, L.; Hou, B.*; Rao, Y.*; Xu, C.* Development of a Highly Selective Ferroptosis Inducer Targeting GPX4 with 2-Ethynylthiazole-4-carboxamide as Electrophilic Warhead. J. Med. Chem. 2025, 68, 3309-3323. (SCI, IF 6.8，中科院大類一區)；

2）Ma, Rongxiang, Renquan Fu, Yifan Wang, Kabonde Makasa Njobvu, Yapeng Fan, Zichao Yang, Mingbing Chen, Feifei Liu, Zhongping Jiang, Yong Rao, Ling Huang, Congjun Xu*, Jianjun Chen*, Jin Liu*, Discovery of Novel Rigid STING PROTAC Degraders as Potential Therapeutics for Acute Kidney Injury. European Journal of Medicinal Chemistry (2025): 117539. (SCI, IF 6.0，中科院一區)

3）Yong Rao*#, Rui Su#, Chenyan Wu#, Xingxing Chai, Jinjian Li, Guanyu Yang, Junjie Wu, Tingting Fu, Zhongping Jiang, Zhikai Guo, Congjun Xu*, Ling Huang*, Identification of a natural PLA2 inhibitor from the marine fungus Aspergillus sp. c1 for MAFLD treatment that suppressed lipotoxicity by inhibiting the IRE-1α/XBP-1s axis and JNK signaling. Acta Pharmaceutica Sinica B, 2023 . (SCI, IF 14.5000，中科院大類一區)

4）Xu, Congjun*; Han, Yufei; Xu, Sicong; Wang, Ruxin; Yue, Ming; Tian, Yu; Li, Xiaofan; Zhao, Yanfang*; Gong, Ping*; Design, synthesis and biological evaluation of new Axl kinase inhibitors containing 1,3,4-oxadiazole acetamide moiety as novel linker, European Journal of Medicinal Chemistry, 2020, 186: 111867. (SCI, IF 7.0878，中科院大類一區)；

5） Mingze Qin*, Yangyang Meng, Haoshen Yang, Lei Liu, Haotian Zhang, Simeng Wang, Chunyang Liu, Xia Wu, Di Wu, Ye Tian, Yunlei Hou, Yanfang Zhao, Yajing Liu,Congjun Xu*, Lihui Wang*, Discovery of 4-Arylindolines Containing a Thiazole Moiety as Potential Antitumor Agents Inhibiting the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction. Journal of Medicinal Chemistry, 2021, 64, 5519–5534 (SCI，IF 8.0385，中科院大類一區)；

6）Yifeng Shen#,Congjun Xu#, Jie Chen#, Zilin Guan, Yanjuan Huang, Zishan Zeng, Xiaoyu Xu, Xiaomin Tan, and Chunshun Zhao*. Photo-triggered self-adaptive “Nano-chameleon”：A Functionalized MOCs-based Drug Delivery Platform Promises high anti-tumor efficacy. Advanced Healthcare Materials. 2021, 10, 2100676. (SCI，IF 11.0926，中科院大類一區)；

7）Congjun Xu‡, Zhanghong Xiao‡, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, yuanfeng He,Yuqi Gao, Chunshun Zhao*. Discovery of A Potent Glutathione Peroxidase 4 Inhibitor as Selective Ferroptosis Inducer. Journal of Medicinal Chemistry,2021,64,13312−13326. (SCI，IF 8.0385，中科院大類一區)；

8）Congjun Xu#, Haolan Yang#, Tao Zhang, Zilin Guan, Jie Chen, Hualu Lai, Xiaoyu Xu, Yanjuan Huang, Zeqian Huang, Chunshun Zhao* Reduction-responsive Dehydroepiandrosterone Prodrug Nanoparticles Loaded with Camptothecin for Cancer Therapy by Enhancing Oxidation Therapy and Cell Replication Inhibition. International Journal of Pharmaceutics. 2021, 603, 120671(SCI，IF 5.875,中科院大類二區，藥學一區);

9）Xu Congjun; Han Yufei; Chen Shaowei; Xu Dengzhi; Zhang Bingfu; Shan Zhenliang; Du Shimei; Xu Liying*; Gong Ping*; One-pot synthesis of 2-methyl-1,5-diaromatic-1H-pyrroles from styrene, acetone and arylamines using TBHP, copper(II) trifluoromethanesulfonate and sulfamic acid, Tetrahedron Letters, 2018, 59(3): 260-263.(SCI，IF 2.415,中科院大類三區)；

10）Xu Congjun#; Qin Mingze#; Yi Jun; Wang Yanjing; Chen Yanfeng; Zhang Bingfu; Zhao Yanfang*; Gong Ping*; Copper(II)-mediated formation of oxazole-4-carbonitrile from acetophenone and coordinated cyanide anion via a radical coupling, RSC Advances, 2017, 7(40): 24643-24646.(SCI，IF 3.361,中科院大類三區)；

11）Huang, Zeqian#; Wei, Gaofei#; Zeng, Zishan; Huang, Yanjuan; Huang, Liangfeng; Shen, Yifeng; Sun, Xiaoqi;Xu, Congjun; Zhao, Chunshun*; Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor, Theranostics, 2019, 9(19): 5542-5557.(SCI, IF 11.556,中科院大類一區)；

12） Huang, Yanjuan#; Jiang, Yali#; Xiao, Zhanghong#; Shen, Yifeng; Huang, Liangfeng,; Xu, Xiaoyu; Wei, Gaofei;Xu, Congjun;Zhao, Chunshun*; Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion, Chemical Engineering Journal, 2019, 380(2020): 122369-122383.(IF 13.273,中科院大類一區)；

13.）Lu, Kuan; Cai, Lude; Zhang, Xue; Wu, Guodong; Xu, Congjun; Zhao, Yanfang; Gong, Ping* Design, synthesis, and biological evaluation of novel substituted benzamide derivatives bearing a 1,2,3-triazole moiety as potent human dihydroorotate dehydrogenase inhibitors. Bioorganic Chemistry, 2018, 76, 528–537.(IF 5.275,中科院大類一區)。

歡迎對科研滿懷熱情的藥學、生物學、基礎醫學相關人才加入。

歡迎具有藥學、化學、生物學背景的同學報考本課題組研究生。