宋英奇  博士  副教授  碩士/博士生導師 海南省D類人才

電子郵箱：996548@hainanu.edu.cn

1.教育背景

2020.09-2023.10 澳門大學 生物醫藥 哲學博士

2017.09-2020.07 四川大學 藥理學專業 理學碩士

2013.09-2017.07 山西中醫藥大學 藥學專業 理學學士

2.科研情況

課題組主要圍繞腫瘤和炎症等藥理學相關疾病模型開展藥物發現、藥物設計、靶向蛋白降解、蛋白-蛋白相互作用、診療一體化等研究。近年來以第一作者或共同第一作者在Chemical Engineering Journal, Small, Acta Pharmaceutica Sinica B, Medicinal Research Reviews, British Journal of Pharmacology, Chinese Chemical Letters, Sensors and Actuators B: Chemical, Journal of Pharmaceutical Analysis, Bioorganic Chemistry等高水平期刊發表多篇SCI論文。

3.研究領域

1）藥理學研究：圍繞腫瘤和炎症等相關疾病模型的分子藥理學機制研究

2）藥物發現：基于高通量篩選發現具有抗腫瘤/抗炎活性的配體用于PROTAC藥物的設計

4.社會兼職

Acta Materia Medica雜志青年編委

5.代表性項目

1）國家自然科學基金-青年科學基金項目，靶向DCLK1蛋白降解劑的設計合成及其抗急性肺損傷活性和機制研究，主持，在研，2025.01-2027.12

2）海南大學科研啟動基金項目，設計合成自噬小體綁定化合物用于降解NAMPT蛋白及其生物活性研究，主持，在研，2023.10-2028.10

6.代表性成果

1）YQ Song^#, YW Xu^#, LJ Yang^#, L Wang^#, SZ Jing, GJ Yang, SH Chan, CY Wong, WH Wang^*, KW Wong^*, CH Leung^*. Probing the AFF4-CCNT1 protein-protein interaction using a metal-organic conjugate for treating triple-negative breast cancer. Chemical Engineering Journal, 2024, 496: 153685.（IF = 13.4，中科院1區）

2）YQ Song, QJ Li, CQ Sheng^*. RMC-7977, a highly selective inhibitor of the active RAS-GTP to treat pancreatic cancer. Acta Pharmaceutica Sinica B, 2024, 14(10):4622.（IF = 14.8，中科院1區）

3）YQ Song, CQ Sheng^*. [¹⁸F]QTFT, a nicotinate-based radiotracer targeting P2Y₁₂ with satisfactory blood-brain barrier (BBB) permeability. Acta Pharmaceutica Sinica B,（Accepted, IF = 14.8，中科院1區）

4）YQ Song^#, KJ Wu^#, ZM Zhang, TM Liu, CN Ko, WG Zhu, DL Ma^*, WH Wang^*, CH Leung^*. Development of a sensitive luminescent probe to uncover new BRD4 inhibitors in living cells. Chemical Engineering Journal. 2023, 463: 142356.（IF = 13.4，中科院1區）

5）YQ Song, GD Li, D Niu, F Chen, SZ Jing, KW Wong, WH Wang^*, CH Leung^*. A robust luminescent assay for screening alkyladenine DNA glycosylase inhibitors to overcome DNA repair and temozolomide drug resistance. Journal of Pharmaceutical Analysis. 2023.（IF = 14.026，中科院1區）

6）YQ Song, GJ Yang^*, DL Ma, WH Wang^*, CH Leung^*. The role and prospect of lysine-specific demethylases in cancer chemoresistance. Medicinal Research Reviews. 2023, 1-32.（IF = 12.388，中科院1區）

7）ML Guo^#, YQ Song^#, JF Cheng, GQ Dong, Xun Sun^*, CQ Sheng^*. Hydrophobic tagging-induced degradation of NAMPT in leukemia cells. Chinese Chemical Letters, 2023: 109392.（IF = 9.1, 中科院1區）

8）SZ Jing^#, YQ Song^#, JQ Liu, C Zhao, L Wang, SH Chan, CY Wong, MY Lee, J Wang^*, CH Leung^*, WH Wang^*. A NIR iridium(III) complex-based luminescence probe for imaging mitochondria pyruvate dehydrogenase kinase 1 in triple-negative breast cancer cells. Sensors and Actuators B: Chemical, 2024, 418: 136265.（IF = 8.0，中科院1區）

9）SS Cheng^#, J Li^#, YQ Song^#, SZ Jing^#, YX Lan, L Wang, SH Chan, CY Wong, CQ Sheng^*, WH Wang^*, HM Wang^*, CH Leung^*. A Bioactive Benzimidazole-cyclometalated Iridium(III) Complex as an Epigenetic Regulator through Effectively Interrupting the EED-EZH2 Interaction. Small, 2025: 2405771.（IF = 13.0, 中科院1區）

10）GJ Yang^#, YQ Song^#, WH Wang, QB Han, DL Ma^*, CH Leung^*. An optimized BRD4 inhibitor effectively eliminates NF-κB-driven triple-negative breast cancer cells. Bioorganic Chemistry, 2021, 114: 105158.（IF = 5.307，中科院1區）

11）LT Liu^#, YQ Song^#, XS Chen^#, Y Liu, JJ Zhu, LM Zhou, SJ Xu, LH Wan^*. Morphine‐induced RACK1‐dependent autophagy in immortalized neuronal cell lines. British Journal of Pharmacology, 2020, 177(7): 1609-1621.（IF = 9.473，中科院1區）

12）YQ Song, C Wu, KJ Wu, QB Han, XM Miao, DL Ma^*, CH Leung^*. Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer. Frontiers in Cell and Developmental Biology. 2021, 9: 665646. （IF = 6.684，中科院2區）

13）R Li^#, YQ Song^#, ZN Ji, L Li^*, LM Zhou^*. Pharmacological biotargets and the molecular mechanisms of oxyresveratrol treating colorectal cancer: Network and experimental analyses. Biofactors, 2020, 46(1): 158-167.（IF = 6.438，中科院2區）

14）SS Cheng, GJ Yang, WH Wang, YQ Song, Ko CN, QB Han, DL Ma^* and CH Leung^*. Identification of a cytisine-based EED-EZH2 protein-protein interaction inhibitor against metastasis in triple-negative breast cancer cells. Acta Materia Medica 1, 2, 197-211.

15）HX Xie, LS Yang, Q Hu, YQ Song, XY Wang, LM Zhou^*, LJ Li^*. Effects of inducing apoptosis and inhibiting proliferation of siRNA on polyadenylate‐binding protein‐interacting protein 1 in tongue cell carcinoma. Head & Neck, 2020, 42(12): 3623-3637.

16）R Li, XY Ma, YQ Song, YY Zhang, WB Xiong, L Li^*, LM Zhou^*. Anti‐colorectal cancer targets of resveratrol and biological molecular mechanism: analyses of network pharmacology, human and experimental data. Journal of Cellular Biochemistry, 2019, 120(7): 11265-11273.

歡迎醫學、藥學等相關及交叉學科研究背景的同學報考本課題組研究生！

歡迎本科生來課題組開展科研學習！