王大勇 男 教授 博士 博士生導師 海南省LJ人才 教育部課程思政教學名師 海南省生物化學與分子生物學會副理事長

郵箱：wangdy@hainanu.edu.cn

通訊地址：海南省海口市美蘭區人民大道58号海南大學熱帶農林主樓817室

郵政編碼：570228

1.研究領域

生物技術與分子藥理學

2.招生專業

博士：生物化學與分子生物學

碩士：生物化學與分子生物學

3.教育背景

2000-09--2003-07 沈陽藥科大學 藥理學專業 博士

1997-09--2000-07 黑龍江中醫藥大學 藥理學專業 碩士

1990-09--1995-07 沈陽藥科大學 英語藥學專業（五年制）學士

4.工作簡曆

2013-04--今 海南大學 生物化學與分子生物學教授

2012-05--2013-04美國伊利諾依大學農業、消費者及環境科學學院動物科學系 Research Specialist

2010-03--2012-05美國伊利諾依大學分子及細胞生物學院 Research Scientist

2007-07--2010-02 美國伊利諾依大學分子及細胞生物學院 Postdoctoral Research Associate

2007-04--2007-06日本名古屋大學醫學部 COE研究員

2004-10--2007-03 日本（原）公定書協會駐名古屋大學附屬醫院藥劑部 Research Resident

2002-04--2004-09 日本名古屋大學大學院神經精神藥理學系 外國人研究員

1995-08-2000-08 （原）哈爾濱市醫藥工業研究所（現）哈藥集團生物工程有限公司 新藥研發項目負責人

5.講授課程

研究生高級生物化學、生物化學、生物技術制藥、神經生物學、細胞生物學、蛋白質工程

6.目前承擔的課題

1）SIRT6-Nrf2蛋白質相互作用與調控及其對基因表達的影響研究（國家自然科學基金），課題負責人

2）調控Keap1與Nrf2相互作用的Keap1蛋白未知磷酸化位點及磷酸化信号傳導通路研究（國家自然科學基金），課題負責人

3）與β澱粉樣蛋白單體相互作用引起JNK-Tau磷酸化的未知蛋白及其介導的細胞信号傳導通路研究（國家自然科學基金），課題負責人

4）基于融合串聯抗原表位的新型疫苗治療熱帶無爪螨過敏症及其作用機理研究（國家自然科學基金），團隊負責人

7.發表論文：

1）Ruijia Fu^#, Yanquan Xu^#, Gang Lu, Fan Zhang, Pei Liang*, Dayong Wang*. Identification and immunological characterization of annexin B8 and annexin E1 from Spirometra erinaceieuropaei spargana. Parasitology Research. 2024 Nov 27;123(11):398.

2）Lianmeng Ye, Jiazheng Zhao, Zhengpan Xiao, Wenyu Gu, Xiaoxuan Liu, Nuela Manka’a Che Ajuyo, Yi Min*, Yechun Pei* and Dayong Wang*. Integrative Human Genetic and Cellular Analysis of the Pathophysiological Roles of AnxA2 in Alzheimer’s Disease. Antioxidants. 2024, 13:1274.

3）Fangfang Ran, Chunyu Xiang, Changyi Wang, Yuwei Zang, Liangwang Liu, Shuwen Wu, Congcong Wang, Jie Cai, Dayong Wang*, Yi Min*. Identification of the 4CL family in cassava (Manihot esculenta Crantz) and expression pattern analysis of the Me4CL32 gene. Biochemical and Biophysical Research Communications. 2024, 735:150731.

4）Jiang Wang, Jingyi Yang, Pradeepraj Durairaj, Wei Wang, Dongyan Wei, Shi Tang, Haiqing Liu, Dayong Wang*, Ai-Qun Jia*. Discovery of β-nitrostyrene derivatives as potential quorum sensing inhibitors for biofilm inhibition and antivirulence factor therapeutics against Serratia marcescens. mLife. 2024, 3(3):445-458.

5）Lianmeng Ye^#, Nuela Manka’a Che Ajuyo^#, Zhongyun Wu, Nan Yuan, Zhengpan Xiao, Wenyu Gu, Jiazheng Zhao, Yechun Pei, Yi Min*, Dayong Wang*. Molecular Integrative Study on Inhibitory Effects of Pentapeptides on Polymerization and Cell Toxicity of Amyloid-β Peptide (1–42). Current Issues in Molecular Biology. 2024, 46:10160-10179.

6）Wenyu Gu, Xinli Cong, Yechun Pei, Nuela Manka'a Che Ajuyo, Yi Min*, Dayong Wang*. Impaired mitochondrial energy metabolism regulated by p70S6K: A putative pathological feature in Alzheimer's disease. Metabolites. 2024 Jun 29; 14(7):369.

7）Yan Sun, Dayong Wang*. Protein-Engineered Hirudins with Enhanced Anticoagulant Activities Developed by a Molecular Integrative Approach. Journal of Medicinal Chemistry. 2024, Mar 14; 67(5):3203-3204.

8）Pei Liang^#, Pei Liang^#, Peng Liang, Kemin Chen, Zhengxin Chen, Yamei Liu, Yujin Lin, Jin Li, Ruijia Fu, Gang Lu* and Dayong Wang*. Important nutrient sources and carbohydrate metabolism patterns in the growth and development of spargana. Parasites & Vectors. 2024, (2024) 17:68-83.

9）Yuwei Zang, Yechun Pei, Xinli Cong, Fangfang Ran, Liangwang Liu, Changyi Wang, Dayong Wang*, Yi Min*. Single-cell RNA-sequencing profiles reveal the developmental landscape of the Manihot esculenta Crantz leaves. Plant Physiology. 2024, January, 194(1):456-474.

10）Jiang Wang^#, Jing-Yi Yang^#, Pradeepraj Durairaj, Wei Wang, Shi Tang*, Dayong Wang*, Chao-Yun Cai, Ai-Qun Jia*. Developing 3‑(2-Isocyano-6-methylbenzyl)‑1H‑indole derivatives to enhance the susceptibility of Serratia marcescens by occluding quorum sensing. ACS Infectious Diseases. 2023, Dec 8;9(12):2607-2621.

11）Zhongyun Wu^#, Lianmeng Ye^#, Nan Yuan^#, Che Ajuyo Nuela Manka’a, Zhengpan Xiao, Liangwang Liu, Zuqian Chen, Yechun Pei*, Yi Min*, Dayong Wang*. A molecular integrative study on the inhibitory effects of WRR and ERW on Amyloid β peptide (1-42) polymerization and cell toxicity. Polymers. 2023, 15(22):4356-4370.

12）陳祖倩，肖正泮，魏春潔，臧彧偉，從心黎*，王大勇*. 靶向程序性細胞死亡配體1的多肽抑制劑篩選及抗腫瘤活性評價. 中國熱帶醫學. 2023, 23(11):1134-1140.

13）Changyi Wang, Fangfang Ran, Yuwei Zang, Liangwang Liu, Dayong Wang*, Yi Min*. Genome-wide identification and expression analysis of heat shock protein gene family in cassava. Plant Genome. 2023 Oct 29:e20407.

14）Nan Yuan^#, Lianmeng Ye^#, Yan Sun, Hao Wu, Zhengpan Xiao, Wanmeng Fu, Zuqian Chen, Yechun Pei, Yi Min*, Dayong Wang*. Molecular Integrative Analysis of the Inhibitory Effects of Dipeptides on Amyloid β Peptide 1-42 Polymerization. International Journal of Molecular Sciences. 2023, 24(8):7673-7693.

15）Yutong Cui, Jiani Han, Hong Li, Xiang Ma, Yanqiong Tang, Yong Deng, Dayong Wang, Denggao Huang, Juanjuan Li, Zhu Liu. Ultrasound mediated gold nanoclusters-capped gas vesicles for enhanced fluorescence imaging. Photodiagnosis and Photodynamic Therapy. 2023, 43:103737.

16）Wanmeng Fu^#, Zhengpan Xiao^#, Yibo Chen, Jinli Pei, Yan Sun, Zhuandan Zhang, Hao Wu, Yechun Pei, Shuangshuang Wei, Yuerong Wang*, Dayong Wang*. Molecular integrative study on interaction domains of nuclear factor erythroid 2-related factor 2 with sirtuin 6. Biochimie. 2023, 211:68-77.

17）劉良旺, 臧彧偉, 冉方芳, 闵義*, 王大勇*. FtsZ靶向多肽抑制劑的分子對接、分子動力學分析及抗菌活性評價. 熱帶生物學報. 2023, 14(3):269-278.

18）Jinjia Song, Benji Fan, Xiaodie Shao, Yuwei Zang, Dayong Wang* and Yi Min*. Single-cell transcriptome sequencing atlas of cassava tuberous root. Frontiers in Plant Science. 2023; Jan 04; 2023, 13:1053669.

19）Jinli Pei, Baochun Wang*, Dayong Wang*. Current Studies on Molecular Mechanisms of Insulin Resistance. Journal of Diabetes Research. 2022; Dec 23, 2022:1863429.

20）Yechun Pei*^{, #}, Zhengpan Xiao^#, Shuangshuang Wei, Meiqi Peng, Chenghui Luo, Dayong Wang*. Studies on HBcAg-rBlo t 5-21 Fusion Protein Vaccine That Alleviates Blomia tropicalis Airway Inflammation. Journal of Inflammation Research. 2022, 15:6343-6355.

21）Yue-Xiang Zeng, Jun-Sheng Liu, Ying-Jie Wang, Shi Tang, Da-Yong Wang, Shi-Ming Deng, Ai-Qun Jia*. Actinomycin D: a novel Pseudomonas aeruginosa quorum sensing inhibitor from the endophyte Streptomyces cyaneochromogenes RC1. World J Microbiol Biotechnol. 2022 Jul 29;38(10):170.

22）Ruijia Fu, Pei Liang, Gang Lu, Jinbao Gu, Dayong Wang*. Prevalence of sparganum infection in wild frogs in Hainan province of China involves a risk for sparganosis. American Journal of Translational Research. 2022; 14(3):1826-1837.

23）Yan Sun, Baochun Wang, Jinli Pei, Ying Luo, Nan Yuan, Zhengpan Xiao, Hao Wu, Chenghui Luo, Jiaxuan Wang, Shuangshuang Wei, Yechun Pei, Shengmiao Fu, Dayong Wang*. Molecular dynamic and pharmacological studies on protein-engineered hirudin variants of Hirudinaria manillensis and Hirudo medicinalis. British Journal of Pharmacology. 2022, 179(14):3740-3753.

24）Pei Liang, Xiuji Cui, Ruijia Fu, Peng Liang, Gang Lu, Dayong Wang*. Identification of an enolase gene and its physiological role in Spirometra mansoni. Parasitology Research. 2021, May (25), 120(6):2095-2102.

25）Shuangbao Li, Peng Cao, Congcong Wang, Jianchun Guo, Yuwei Zang, Kunlin Wu, Fangfang Ran, Liangwang Liu, Dayong Wang*, Yi Min*. Genome-wide analysis of tubulin Gene family in cassava and expression of family member FtsZ2-1 during various stress. Plants (Basel). 2021, 10:668-685.

26）Jinli Pei, Zhengpan Xiao, Ziyi Guo, Yechun Pei, Shuangshuang Wei, Hao Wu, Dayong Wang*. Sustained stimulation of β2AR inhibits insulin signaling in H9C2 cardiomyoblast cells through the PKA-dependent signaling pathway. Diabetes Metabolic Syndrome and Obesity-Target & Therapy. 2020, 2020(13):3887-3898.

27）張轉丹, 肖正泮, 武新麗, 孫豔, 羅應, 吳昊, 韋雙雙, 裴業春*, 王大勇*. 魚類神經壞死病毒衣殼蛋白MCP和鮰愛德華氏菌外膜蛋白ompN1融合基因的原核表達. 熱帶生物學報. 2020; 11(2):145-155.

28）Hao Wu, Shuangshuang Wei, Yonglin Huang, Lintao Chen, Yuerong Wang, Xinli Wu, Zhuandan Zhang, Yechun Pei*, Dayong Wang*. Aβ monomer induces phosphorylation of Tau at Ser-214 through β2AR-PKA-JNK signaling pathway. FASEB Journal. 2020 Apr; 34(4):5092-5105.

29）武新麗, 韋雙雙, 裴業春, 趙景鋒, 王大勇*. 反相高效液相色譜法對小鼠血清中基因重組人促腎上腺皮質激素前體及其代謝物的測定. 熱帶生物學報. 2019, 10(1):83-88.

30）Jinli Pei, Shuangshuang Wei, Yechun Pei, Hao Wu, Dayong Wang*. Role of dietary gluten in development of celiac disease and type I diabetes: management beyond gluten-free diet. Current Medicinal Chemistry. 2020,27(21):3555-3576.

31）Shuangshuang Wei, Yechun Pei, Yuerong Wang, Huai Guan, Yonglin Huang, Tian Xing, Rodney W. Johnson, Dayong Wang*. Role of human Keap1 S53 and S293 residues in modulating the binding of Keap1 to Nrf2. Biochemie. 2019,158:73-81.

32）Yuan Zhou^#, Lintao Chen^#, Xi Zhou, Yechun Pei, Shuangshuang Wei, Anum Mehmood, Yang K. Xiang, Dayong Wang*. Profiling of Differential Expression of Genes in Mice Carrying Both Mutant Presenilin 1 and Amyloid Precursor Protein Transgenes with or without Knockout of Β2 Adrenergic Receptor Gene. Journal of Applied Bioinformatics and Computational Biology. 2018, 7(3):155-168.

33）陳林濤, 韋雙雙, 黃永林, 吳昊, 郭子怡, 陳銀華*, 王大勇*. 重組人血清白蛋白在紫花苜蓿中的轉基因表達. 熱帶作物學報. 2018, 39(4):720-725.

34）肖正泮, 劉金瑩, 韋雙雙, 王大勇, 裴業春. 重組熱帶螨Blo t 21變應原誘導小鼠變态反應氣道炎症模型的建立, 熱帶生物學報, 2017, 8 (3):371-376.

35）Yuerong Wang, Shuangshuang Wei, Lintao Chen, Jinli Pei, Hao Wu, Yechun Pei, Yibo Chen, Dayong Wang*. Transcriptomic analysis of gene expression in mice treated with troxerutin. PLOS ONE. 2017, 12(11): e0188261.

36）Yonglin Huang¹, Yechun Pei¹, Huai Guan, Shuangshuang Wei, Hao Wu, Yuan Zhou, Jinli Pei, Lintao Chen, Yuerong Wang, Yibo Chen, Qian Han, Daming Wang, Dayong Wang*. Stability and Pharmacological Effects of Gene-Recombinant Wild Type and Mutant Human Adrenocorticotropic Hormone. Pharmaceutical Research. 2017, 34(4):793-799.

37）肖正泮, 韋雙雙, 關懷, 王大勇, 裴業春*. 熱帶無爪螨主要變應原Blo t 21抗原表位的預測. 熱帶醫學雜志. 2017, 17 (7):841-845.

38）王曉哲, 肖正泮, 韋雙雙, 王大勇, 裴業春*. 利用DNAStar軟件預測熱帶無爪螨主要緻敏原Blo t 5的抗原表位. 熱帶生物學報. 2017, 8(1):90-95.

39）黃永林, 韋雙雙, 裴業春, 吳昊, 王大勇*. 基因重組長效人促腎上腺皮質激素藥理學活性. 沈陽藥科大學學報. 2016, 33(12):996-1000.

40）裴業春, 安曉榮, 侯健, 陳永福, 闫鳳祥, 關宏, 韋雙雙, 王大勇*. 貓重組變應原Fel d 1與乙肝病毒核心抗原融合基因的原核表達. 中國畜牧獸醫. 2016, 43(11):2826-2833.

41）Dayong Wang, Qin Fu, Yuan Zhou, Qian Shi, Benedict Igwe, Elena V. Wisely, Salvatore Oddo, Yang K. Xiang. β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer’s disease models. Journal of Biological Chemistry. 2013, 288(15):10298-10307.

42）Ruijie Liu, Dayong Wang, Qian Shi, Qin Fu, Steven Hizon, Yang K. Xiang. Palmitoylation Regulates Intracellular Trafficking of β2 Adrenergic Receptor/Arrestin/Phosphodiesterase 4D Complexes in Cardiomyocytes. PLOS ONE. 2012,7(8):e42658

43）Dayong Wang, Eunice Yuen, Yuan Zhou, Yan Zhen, Yang K. Xiang. Amyloid beta peptide-(1-42) induces internalization and degradation of beta2 adrenergic receptors in prefrontal cortical neurons. Journal of Biological Chemistry. 2011, 286(36):31852-63.

44）Dayong Wang, Yang K. Xiang. β-adrenergic receptor, amyloid Abeta, and Alzheimer’s disease. Current Topics in Membranes: Advances in Adrenergic Receptor Biology. 2011, 67: 205-229.

45）Dayong Wang, G. Govindaiah, Ruijie Liu, Vania De Arcangelis, Charles Lee Cox, Yang Xiang. Binding of Amyloid β peptide to β₂ adrenergic receptor induces PKA dependent AMPA receptor hyperactivity. FASEB Journal. 2010, 24(9):3511-21.

46）Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshima. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The International Journal of Neuropsychopharmacology. 2010, 13(10):1343-54.

47）Hiroko Tsunekawa, Yukihiro Noda, Masayuki Miyazaki, Fumio Yoneda, Toshitaka Nabeshima, Dayong Wang. Effects of (R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of mood disorders. Behavioural Brain Research. 2008, 189(1): 107-116.

48）Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Role of N-Methyl-D-aspartate receptors in antidepressant-like effects of σ₁ receptor agonist 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine dihydrochloride (SA-4503) in olfactory bulbectomized rats. Journal of Pharmacology and Experimental Therapeutics. September, 2007, 322(3): 1305-1314.

49）Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of combined treatment with risperidone and galantamine on phencyclidine-induced impairment of latent visuospatial learning and memory: role of nAChR activation-dependent increase of dopamine D1 receptor-mediated neurotransmission. Neuropharmacology. September, 2007, 53(3): 379-89.

50）Dayong Wang, Yukihiro Noda, Yuan Zhou, Akihiro Mouri, Hiroyuki Mizoguchi, Atsumi Nitta, Weiduo Chen, Toshitaka Nabeshima. The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid_25-35 i.c.v.-injected mice: involvement of dopaminergic systems. Neuropsychopharmacology. 2007, 32(6): 1261-1271.

51）Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima. Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model. Neuropharmacology. 2007, 52(4): 1179-87.

52）Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Toshitaka Nabeshima. Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety. Behavioural Brain Research. 2007, 178(2): 262-73.

53）王大勇, 于慶海, 周園, Yukihiro Noda, Toshitaka Nabeshima. 現代免疫佐劑研究.《中國免疫學雜志》. 2006, 22(2): 189-192.

54）周園, 王大勇, 王劍楠, 孫凱, 王玉紅, 陳維多. 長效基因工程豬α-1幹擾素生産工藝的優化研究.《黑龍江畜牧獸醫》. 2006, 49(6):83-85.

55）周園, 陳維多, 王大勇, 蘇雲明. 重組人α-2b幹擾素發酵及粗提條件的優化研究.《黑龍江醫藥》.2006, 19(1):35-38.

56）Li-Bo Zou, Akihiro Mouri, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Hiroyuki Mizoguchi, Yukihiro Noda and Toshitaka Nabeshima. Inhibition of neprilysin by infusion of thiorphan into the hippocampus causes an accumulation of amyloid {beta} and impairment of learning and memory. Journal of Pharmacology and Experimental Therapeutics. 2006, 317(1): 334-40.

57）Dayong Wang, Yukihiro Noda, Toshitaka Nabeshima. Features of olfactory bulbectomized rat model of depression and effects of sigma₁ receptor agonist. Japanese Journal of Molecular Psychiatry. 2006, 6(2): 81-84.

58）Akihiro Mouri, Li-Bo Zou, Nobuhisa Iwata, Takaomi C. Saido, Dayong Wang, Min-Wei Wang, Yukihiro Noda and Toshitaka Nabeshima. Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behavioral Brain Research. 2006,168(1): 83-91.

59）Takeshi Enomoto, Yukihiro Noda, Akihiro Mouri, Eun-Joo Shin, Dayong Wang, Rina Murai, Kazuo Hotta, Hiroshi Furukawa, Atsumi Nitta, Hyoung-Chun Kim, and Toshitaka Nabeshima. Long-Lasting Impairment of Associative Learning Is Correlated with a Dysfunction of N-Methyl-D-aspartate- Extracellular Signaling-Regulated Kinase Signaling in Mice after Withdrawal from Repeated Administration of Phencyclidine. Molecular Pharmacology. 2005, 68: 1765-1774.

60）Hiroko Tsunekawa, Yukihiro Noda, Dayong Wang, Hiroyuki Mouri, Toshitaka Nabeshima. Selegiline potentiates effects of donepezil on cognitive impairment induced by amyloid beta (25-35). Bulletin of the Japanese Society for Neurochemistry. 2005, 44: 182.

61）Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Toshitaka Nabeshima and Qinghai Yu. Effects of sodium houtuyfonate on phosphorylation of CaMK II, CREB and ERK 1/2 and expression of c-Fos in macrophages. International Immunopharmacology. 2004, 8: 1083-1088.

62）Tsunekawa Hiroko, Yukihiro Noda, Dayong Wang, Toshitaka Nabeshima. Antidepressive effect of (R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of stress disorders. Journal of Pharmacological Science. 2004, 94 (suppl.): 225P.

63）王大勇, 畢秀麗, 周園, 彭纓, 野田幸裕, 鍋島俊隆. 合成魚腥草素對巨噬細胞呼吸爆發、細胞内遊離鈣離子濃度及T細胞分泌白細胞介素-2的影響.《沈陽藥科大學學報》. 2003, 20(3):210-214.

64）Dayong Wang, Qinghai Yu, Peggy Eikstadt, Darcy Hammond, Yun Feng, and Na Chen. Studies on adjuvaticity of sodium houttuyfonate and its mechanism. International Immunopharmacology. 2002, 10:1411-1418.

65）Dayong Wang, Qinghai Yu, Yun Feng, and Na Chen. Adjuvanticity of sodium houttuyfonate. Indian Journal of Pharmacology. 2002, 34(5):363-364.

66）王立強, 丁一兵, 周園, 王大勇. 6,7-二甲氧基香豆素對豚鼠心房DME及家兔胃電的影響.《沈陽藥科大學學報》. 2001, 18(增刊): 87-88.

67）孟慶林, 王立強, 聶鳳文, 周園, 王大勇. 茵陳膠囊降血脂作用實驗研究.《沈陽藥科大學學報》. 2001, 18(增刊):89-90.

68）周慧秋, 于濱, 喬萬紅, 王大勇, 張萬榮, 蘇雲明. 甲基丁香酚藥理作用研究.《中醫藥學報》. 2000, 28(2):79-80.

8.申報的發明專利

1）王大勇, 闵義, 劉良旺, 裴業春, 從心黎, 韋雙雙. 一種具有抑菌作用的FtsZ蛋白抑制劑及其應用. 發明專利号：ZL202410829056.1，授權日期：2025-02-18.

2）王大勇, 吳鐘雲, 葉連萌, 袁楠. 抑制Aβ42聚集并降低其細胞毒作者用的三肽化合物（專利分案）. 發明專利号：ZL202410276051.0，授權日期：2024-11-12

3）王大勇, 吳鐘雲, 葉連萌, 袁楠. 抑制Aβ42聚集并降低其細胞毒作者用的三肽化合物. 發明專利号：ZL202311193904.6，授權日期：2024-04-05

4）王大勇, 孫豔, 王葆春, 王大欣, 裴業春, 韋雙雙, 闵義, 請求不公布姓名, 請求不公布姓名, 請求不公布姓名. 具備較強抗凝血活性的醫蛭基因重組水蛭素及其制備方法. 發明專利号：ZL202110840069.5，授權日期：2024-03-08

5）王大勇，孫豔，王葆春，王大欣，符生苗，禹勃，耿雷，宋少江，請求不公布姓名. 一組活性增強代謝較慢的菲牛蛭基因重組水蛭素及其制備方法. 發明專利号：ZL202110688404.4，授權日期：2024-02-06

6）王大勇，武新麗. 一組提高血清糖皮質激素水平的基因重組人促皮質素前體及制備方法. 發明專利号：ZL201910143665.0，授權日期：2022-07-09

7）王大勇，陳林濤. 一種用紫花苜蓿表達的基因重組人血清白蛋白及表達方法. 發明專利号：ZL201711336264.4，授權日期：2021-06-01

8）王大勇，從心黎，陳祖倩，趙聖印，裴業春，闵義，韋雙雙. 一種具有抗腫瘤作用的化合物BP220805及其制備方法和應用. 發明專利号：ZL202410807608.9，授權日期：2025-05-13.

9.成果與獎勵

1）（原）美國National Alliance of Research on Schizoprenia and Depression (NARSAD) 2009青年研究員獎

2）美國伊利諾伊大學分子及細胞生物學院學術論壇一等獎

3）主持完成美國腦與行為研究基金會項目

4）主持完成美國伊利諾依州公衆衛生部阿爾茨海默病研究基金項目

5）主持完成國家和省自然科學基金項目