石東磊 男 博士 副研究員 博（碩）士生導師

電子郵箱：996476@hainanu.edu.cn; 1119212452@qq.com

2023年7月通過高層次人才引進到365英国上市官网在线工作。

1.教育背景

2011.09-2015.06 黑龍江大學 制藥工程 學士

2016.09-2019.06 西北大學 材料工程 碩士

2020.09-2023.06 華東理工大學 藥 學 博士

2. 科研情況

聚焦衰老及相關疾病的精準診斷與治療前沿，開展衰老進程精準識别探針分子與診療一體化藥物分子研發。一方面，設計合成衰老進程精準識别探針分子，用以可視化研究衰老發生機制，輔助抗衰老藥物研發；設計合成實用型衰老識别探針，構建藥物篩選平台，高通量、快捷評價、篩選抗衰老藥物。另一方面基于衰老進程發生機制，設計合成診療一體化抗衰老藥物分子，精準可視化靶向作用于衰老細胞，延緩機體衰老進程、治療衰老相關疾病。以第一/共一/共通作者身份在Nature Aging、Chemical Science、Journal of Medicinal Chemistry、Sensors and actuators B-Chemical等期刊發表論文12篇，申請發明專利6項。

3.研究領域

衰老及相關疾病的精準可視化診療：有機小分子熒光探針/光敏分子、senolytic/senomorphic藥物分子和設計合成

4. 代表性項目

國家自然科學基金青年基金項目，2025-2027，主持

海南省自然科學基金面上項目，2025-2027，主持

海南大學科研啟動基金項目，2024-2029，主持

5. 代表性成果

[1] Yangxin Yu†; Xinhang Lv†; Zhuowei Chen†; ...; Jian Li*; Donglei Shi*, Synergistic effects of activatable photodynamic therapy and crisaborole for psoriasis through senolysis and immunomodulation, J. Med. Chem., 2025, 68, 16395-16409.

[2] Xinhang Lv†; Yangxin Yu†; Zhuowei Chen†; ...; Jian Li*; Yuan Guo*; Donglei Shi*, Molecular engineering development of β-galactosidase-activatable fluorogenic probes for precise senescence tracking in cells, tissues and a mouse model of psoriasis, Sens. Actuators B, 2025, 444, 138406.

[3] Donglei Shi†; Wenwen Liu†; Ying Gao†; …; Yuan Guo*; Jian Li*, Photoactivatable senolysis with single-cell resolution delays aging, Nat. Aging, 2023, 3, 297-312. (Research Briefing, Nat. Aging, 2023, 3, 244-245；News & Views, Nat. Chem., 2023, 15, 451-452.)

[4] Donglei Shi†; Shuqiang Chen†; Biao Dong†; ...; Yuan Guo*, Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe, Chem. Sci., 2019, 10, 3715-3722.

[5] Xu Qu†, Pengzhao Wu†, Kaixuan Duan†, …, Yuan Guo*, Jianjian Zhang*, Donglei Shi*, Self-calibrating probes constructed on a unique dual-emissive fluorescence platform for the precise tracking of cellular senescence. Chinese Chem. Lett. 2024, 12, 109681.

[6] Donglei Shi†; Linghao Hu†; Xinming Li†; …; Yuan Guo*, Jian Li*, Lysosomal polarity increases with aging as revealed by a lysosome-targetable near-infrared fluorescent probe, Sens. Actuators B, 2020, 319, 128302.

[7] Donglei Shi†; Wenwen Liu†; Guangwei Wang; Yuan Guo*; Jian Li*, Small-molecule fluorescence-based probes for aging diagnosis, Acta Materia Medica, 2022, 1, 4-23

[8] Jingye Tian†; Donglei Shi†; Yanhui Zhang†; …; Jian Li*; Yuan Guo*, Stress response decay with aging visualized using a dual-channel logic based fluorescent probe, Chem. Sci., 2021, 12, 13483-13491.

[9] Huan Wang†; Donglei Shi†; …; Jian Li; Yuan Guo*, A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells, Sens. Actuators B, 2018, 256, 600-608.

[10] Linghao Hu†; Donglei Shi†; Xinming Li†; …; Yuan Guo*; Jian Li*, Curcumin-based polarity fluorescent probes: Design strategy and biological applications, Dyes Pigments, 2020, 177, 108320.

[11] Yihe Song†; Xinming Li†; Donglei Shi†; …; Yuan Guo*; Jian Li*, A senolysis-based theragnostic prodrug strategy towards chronic renal failure, Chem. Sci., 2022, 13, 11738-11745.

[12] Liangliang Gao; Shuli Pan; Ying Gao; Donglei Shi*; Yuan Guo*, Recent development of organic small-molecule and nanomaterial fluorescent probes for hydrazine, Advanced Agrochem, 2022, 1, 22-38.

歡迎具有藥物化學/化學生物學背景的同學報考本課題組