劉文文 藥學博士 副教授 碩士生/博士生導師

郵箱：wenwenliu@hainanu.edu.cn

海南省D類人才

1.教育背景

2016.09-2021.06 華東理工大學 藥學專業 博士（碩博連讀）

2012.09-2016.06 安徽理工大學 制藥工程專業 學士

2.教學情況

《藥理學》、《藥理學實驗》、《抗衰老研究進展·延長生命的奧秘》

3.科研情況

瞄準國家重大需求，面向人民生命健康，緻力于衰老（相關疾病）靶标/機制研究與候選新藥研發。

（1）基于老藥庫（化藥+中草藥）開展抗衰老活性篩選、藥效評價、靶标/機制研究和結構優化，已解析10餘種老藥抗衰老新用途。

（2）綜合構建線蟲、細胞（肺、腎、皮膚、角膜内皮、血管内皮細胞等）、小鼠（衰老和器官增齡疾病模型）水平的抗衰老研究平台，包含抗衰老表型篩選→活性确證→靶标鑒定與确證→機制通路研究→結構優化→成藥性評價，助力衰老及相關疾病幹預藥物研發。

（3）在Nature Aging、Advanced Science、Journal of Medicinal Chemistry等期刊發表論文20餘篇；申請專利15項；主持國自然面上項目、國自然青年科學基金項目、海南省科學基金、橫向課題等6項。

4.研究領域

衰老靶标确證和幹預藥物研發

5.社會兼職

Acta Materia Medica首屆青年編委

中國中醫藥信息學會中醫臨床藥學分會理事

Traditional Medicine Research青年編委

6.代表性項目

[1] 國家自然科學基金委員會，面上項目，2025-01至2028-12，在研，主持

[2] 國家自然科學基金委員會，青年科學基金項目，2023-01至2025-12，在研，主持

7.代表性成果

[1] Sicong Qiao^#, Xin Chen^#, Youyou Chen^#, Yihe Song, Donglei Shi, Zhifan Mao, Jian Li*, Yunyuan Huang*, Wenwen Liu*. Discovery of non-antibacterial enrofloxacin derivatives with emerging anti-aging effects through drug repurposing and secondary development. J. Med. Chem. 2025, 68, 14312−14332. (Front cover article)

[2] Liru Chen^#, Deyan Wu^#, Sen Wang, Lingyu Wu, Youyou Chen, Baoli Li, Haibin Luo*, Jian Li*, Wenwen Liu *. Moracin M derivative targeting PDE4 for the treatment of psoriasis. Acta Mater. Med. 2025, 4, 293−301.

[3] Zhifan Mao^#, Wenwen Liu ^#, Rong Zou^#, Ling Sun^#, Shuman Huang, Lingyu Wu, Liru Chen, Jiale Wu, Shijie Lu, Zhouzhi Song, Xie Li, Yunyuan Huang, Yong Rao, Yi-You Huang, Baoli Li*, Zelan Hu*, Jian Li*. Glibenclamide targets MDH2 to relieve aging phenotypes through metabolism-regulated epigenetic modification. Sig. Trans duct. Target. Ther. 2025, 10, 67.

[4] Jiqun Wang^#, Wenwen Liu^#, Yunyuan Huang^#, Guangwei Wang, Xiaobo Guo, Donglei Shi, Tianyue Sun, Chaojiang Xiao, Chao Zhang, Bei Jiang*, Yuan Guo*, Jian Li*. A senomorphlytic three-drug combination discovered in Salsola collina for delaying aging phenotypes and extending healthspan. Adv. Sci. 2024, 11, 2401862.

[5] Donglei Shi^#, Wenwen Liu ^#, Ying Gao^#, Xinming Li, Yunyuan Huang, Xiaokang Li, Tony D. James, Yuan Guo*, Jian Li*. Photoactivatable senolysis with single-cell resolution delays aging. Nat. Aging 2023, 3, 297–312. (Research Briefing, Nat. Aging 2023, 3, 244–245；News & Views, Nat. Chem. 2023, 15, 451–452)

[6] Jiqun Wang^#, Yunyuan Huang^#, Kaixuan Shi^#, Lingyuan Bao, Chaojiang Xiao, Tianyue Sun, Zhifan Mao, Jiali Feng, Zelan Hu, Zhenghan Guo, Jing Li, Bei Jiang*, Wenwen Liu *, Jian Li*. Nicandra physalodes extract exerts antiaging effects in multiple models and extends the lifespan of Caenorhabditis elegans via DAF-16 and HSF-1. Oxid. Med. Cell. Longev. 2022, 3151071.

[7] Keting Bao^#, Wenwen Liu ^#, Zhouzhi Song^#, Jiali Feng, Zhifan Mao, Lingyuan Bao, Tianyue Sun, Zelan Hu*, Jian Li*. Crotamiton derivative JM03 extends lifespan and improves oxidative and hypertonic stress resistance in Caenorhabditis elegans via inhibiting OSM-9. eLife 2022, 11, e72410.

[8] Zhifan Mao^#, Wenwen Liu ^#, Yunyuan Huang, Tianyue Sun, Keting Bao, Jiali Feng, Alexey Moskalev, Zelan Hu*, Jian Li*. Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species. Acta Pharm. Sin. B 2022, 12, 665–677.

[9] Donglei Shi^#, Wenwen Liu ^#, Guangwei Wang, Yuan Guo*, Jian Li*. Small-molecule fluorescence-based probes for aging diagnosis. Acta Mater. Med. 2022, 1, 4–23.

[10] Wenwen Liu ^#, Yunhui Guan^#, Sicong Qiao, Jiqun Wang, Keting Bao, Zhifan Mao, Liang Liao, Alexey Moskalev, Bei Jiang, Jin Zhu, Conglong Xia*, Jian Li*, Zelan Hu*. Antiaging effects of Vicatia thibetica de Boiss root extract on Caenorhabditis elegans and doxorubicin-induced premature aging in adult mice. Oxid. Med. Cell. Longev. 2021, 9942090.

[11] Wenwen Liu ^#, Huiling Lin^#, Zhifan Mao^#, Lanxin Zhang, Keting Bao, Bei Jiang, Conglong Xia, Wenjun Li, Zelan Hu*, Jian Li*. Verapamil extends lifespan in Caenorhabditis elegans by inhibiting calcineurin activity and promoting autophagy. Aging-US 2020, 12, 5300–5317.

[12] Wenwen Liu ^#, Huan Wang^#, Xiaokang Li^#, Yixiang Xu, Jian Zhang, Wei Wang, Qi Gong, Xiaoxia Qiu, Jin Zhu, Fei Mao*, Haiyan Zhang*, Jian Li*. Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment. Bioorg. Med. Chem. 2018, 26, 3117–3125.

8.榮譽獎勵

陝西省高等學校科學技術研究成果獎，分子導向的生物學衰老精準識别與幹預，特等，6/6

Acta Materia Medica 2024年優秀審稿人

歡迎具有藥學、化學、生物學背景的同學報考本課題組碩士/博士研究生。