江仲平 醫學博士 副教授 博士/碩士生導師 海南省高層次“D類人才”

  郵箱：zpjiang@hainanu.edu.cn

  1.教育背景

  2019.07-2021.07  南方醫科大學        藥物化學  博士後

  2013.09-2019.06  暨南大學（碩博連讀）   中藥化學  博士

  2009.09-2013.06  湖北中醫藥大學       制藥工程  學士

  2.教學情況

 海洋藥物學、高等天然藥物化學、有機波譜分析和藥用植物學等課程教學

  3.科研情況

  長期緻力于海洋天然藥物研究；聚焦在熱帶海洋微生物，進行其資源庫構建，并從中高效、深度挖掘具有抗神經退行性疾病、代謝性疾病和抗病毒活性的藥物先導化合物。近些年，在Chemical Science, Organic Chemistry Frontiers, Chinese Journal of Chemistry和Phytochemistry等天然藥物化學主流期刊發表SCI論文20餘篇，期中一作/通訊論文10餘篇；主持國家自然科學基金青年項目、地區項目和海南省自然科學基金面上等科研項目；擔任CJNM、Fitoterapia等多個SCI雜志審稿人。

4.研究領域

1) 新穎活性海洋天然産物的發現和複雜化合物的結構鑒定

2) 活性天然産物的結構修飾、作用機制與靶标研究

5.代表性科研項目

1) 國家自然科學基金地區項目（82460696）：靶向調控神經炎症的海洋真菌倍半萜内酯類化合物高效挖掘與抗阿爾茲海默病研究，2025.01～2028.12，主持

2) 國家自然科學基金青年項目（82204275）：紅樹植物海漆來源的甘遂烷型FXR激動劑發現、結構優化及其抗NASH活性研究，2023.01～2025.12，主持

3) 海南省自然科學基金面上項目（323MS014），2023.03～2026.02，主持

6.代表性成果

1) Z. P. Jiang,^# S. H. Sun,^# Y. Yu, A. Mándi, J. Y. Luo, M. H. Yang, T. Kurtán,* W. H. Chen,* L. Shen,* and J. Wu.* Discovery of benthol A and its challenging stereochemical assignment: opening up a new window for skeletal diversity of super-carbon-chain compounds. Chem. Sci. 2021, 12, 10197–10206. (IF = 9.825, 中科院一區，Hot off the Press)

2) Z. P. Jiang,^# M. T. Chen,^# X. Xiang, C. J. Xu, Y. Rao, H. Z. Du,* W. S. Li,* L. Huang.* Eutypetides A—E, Structurally Intriguing Polyketides Formed by Intramolecular [4+2] Cycloaddition from Marine-Derived Fungus Eutypella sp. F0219. Chin. J. Chem. 2025, 43, 23—32. (中科院一區，内封面論文)

3) Z. P. Jiang,^# R. Su,^# M. T. Chen, J. Y. Li, H. Y. Chen, L. Yang, F. F. Liu, J. Liu, C. J. Xu, W. S. Li,* Y. Rao,* L. Huang,* Ent-eudesmane sesquiterpenoids with anti-neuroinflammatory activity from the marine-derived fungus Eutypella sp. F0219. Phytochemistry 2024, 223, 114121. (中科院二區)

4) C. Y. Wu,^# Y. Chen,^# M. T. Chen, T. T. Fu, J. Liu, F. F. Liu, C. J. Xu, W. S. Li, B. L. Li, Z. P. Jiang,* Y. Rao,* L. Huang.* Natural linoleic acid from marine fungus Eutypella sp. F0219 blocks KEAP1/NRF2 interaction and ameliorates MASLD by targeting FABP4. Free Radic. Biol. Med. 224 (2024) 630–643. (中科院二區Top)

5) J. Y. Li,^# L. Yang,^# M. B, Chen, Y. Rao, Z. P. Jiang,* L. Huang,* Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities. Chin. J. Org. Chem. 2024, 44, xxxx～xxxx, DOI: 10.6023/cjoc202404024.

6) W. S. Li,^# X. P. Lei,^# X. T. Yan, Y. Y. Qin, G. Y. Chen, S. Li,* Z. P. Jiang,* Hainanxylogranolides A–F: New Limonoids isolated from the seeds of Hainan mangrove plant Xylocarpus granatum. Fitoterapia 165 (2023) 105407.

7) J. Wu,^#* Z. P. Jiang,^# R. J. Yan, S. H. Sun, Y. Yu, L. Shen,* Gibbosolide A, a highly functionalized 20-membered macrolide with a terminal cis-fused 2-methylhexahydro-2H-furo[3,2-b]pyran motif: insights into late-stage cyclization of marine macrolides. Org. Chem. Front. 2021, 8, 5756–5765. (中科院一區)

8) Z. P. Jiang, Y. Yu, L. Shen.* Agallolides A-M, including two rearranged ent-atisanes featuring a bicyclo[3.2.1]octane motif, from the Chinese Excoecaria agallocha. Bioorg. Chem. 2020, 104: 104206. (中科院二區Top)

9) Z. P. Jiang^#, Z. L. Luan^#, R. X. Liu, Q. Zhang, X. C. Ma, L. Shen,* J. Wu.* Mangrove Tirucallane-and Apotirucallane-Type Triterpenoids: Structure Diversity of the C-17 Side-Chain and Natural Agonists of Human Farnesoid/Pregnane–X–Receptor. Mar. Drugs. 2018, 16(12), 488. (中科院二區)

10) Z. P. Jiang, B. H. Zou, X. J. Li, J. J. Liu, L. Shen,* J. Wu.* Ent-kauranes from the Chinese Excoecaria agallocha L. and NF-κB inhibitory activity. Fitoterapia 2019, 133, 159–170.

11) Z. P. Jiang, L. W. Tian, L. Shen,* J. Wu.* Ent-abietanes from the Godavari mangrove, Ceriops decandra: Absolute configuration and NF-κB inhibitory activity. Fitoterapia 2018, 130, 272–280.

歡迎具有藥學、化學、生物學背景，對海洋天然藥物化學滿懷熱情的同學報考本課題組研究生。