黃儀有 博士 研究員 博士/碩士生導師

 郵箱：742646380@qq.com

  1.教育背景及工作經曆

  2021. 09 –         365英国上市官网在线，研究員

  2020. 09 – 2021. 08 中山大學365英国上市官网在线，特聘副研究員

  2018. 09 – 2020. 08 中山大學365英国上市官网在线，博士後

  2015. 09 – 2018. 06 中山大學365英国上市官网在线，藥物化學博士

  2011. 09 – 2014. 06 中山大學365英国上市官网在线，藥物化學碩士

  2007. 09 – 2011. 06 南方醫科大學365英国上市官网在线，藥學學士

  2.科研情況 

利用X射線晶體學等結構生物學技術手段，解析藥物靶标的三維結構，并以靶标為中心開展藥物設計和藥物化學等藥學研究，特别是圍繞磷酸二酯酶(PDEs)及其選擇性抑制劑的開發等進行相關研究。主持國家自然科學基金面上項目、國家自然科學基金青年基金、海南省自然科學基金面上項目等6項基金，并在國内外重要學術期刊如Proc Natl Acad Sci USA、J Med Chem、Acta Pharm Sin B、Org Lett等發表SCI論文30餘篇，其中（并列）一作/（共同）通訊論文有18篇，授權發明專利4項。

3.研究領域

結構生物學及基于靶标結構的藥物設計

4.代表性項目

1)國家自然科學基金面上項目，2023-2026，主持

2)國家自然科學基金青年基金，2021 – 2023，主持

3)海南省自然科學基金面上項目，2022-2024，主持

4)海南大學科研啟動經費，2021 – 2026，主持

5)中國博士後科學基金面上資助，2019 – 2020，主持

6)中山大學高校基本科研業務費青年教師培育項目，2018 – 2021，主持

5.代表性成果

 1）Deyan Wu^#, Xuehua Zheng^#, Runduo Liu, Zhe Li, Zan Jiang, Qian Zhou, Yue Huang, Xu-Nian Wu, Chen Zhang, Yi-You Huang^*, Hai-Bin Luo^*. Free energy perturbation (FEP)-guided scaffold hopping. Acta Pharm. Sin. B. 2022, 12: 1351-1362.

2）Yuncong Yang^#, Sirui Zhang^#, Qian Zhou^#, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang^*, Lei Guo^*, Hai-Bin Luo^*. Discovery of Highly Selective and Orally Available Benzimidazole-based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for Treatment of Pulmonary Arterial Hypertension. Acta Pharm. Sin. B. 2020, 10: 2339-2347.

3）Haobai Liu^#, Quan Wang^#, Yue Huang^#, Jinhui Deng, Xi Xie , Jiaqi Zhu , Yijun Yuan , Yue-Ming He, Yi-You Huang^*, Hai-Bin Luo^*, Xixin He^*. Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur. J. Med. Chem. 2022, 242: 114631.

4）Feng Zhou^#, Yue Huang^#, Lu Liu^#, Zhendong Song, Ke-Qiang Hou, Yifan Yang, Hai-Bin Luo, Yi-You Huang^*, Xiao-Feng Xiong^*. Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects. Biochem. Pharmacol. 2022, 202: 115123.

5）Yi-You Huang^#, Jinhui Deng^#, Yi-Jing Tian^#, Jinhao Liang, Xi Xie, Yue Huang, Jiaqi Zhu, Ziran Zhu, Qian Zhou, Xixin He^*, Hai-Bin Luo^*. Mangostanin Derivatives as Novel and Orally Active PDE4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety.J. Med. Chem. 2021. 64, 13736-13751.

6）Yi-You Huang^#, Yan-Fa Yu^#, Chen Zhang^#, Yiping Chen, Qian Zhou, Zhuoming Li, Sihang Zhou, Zhe Li, Lei Guo, Deyan Wu^*, Yinuo Wu^*, Hai-Bin Luo^*. Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors. J. Med. Chem. 2019, 62: 3707-3721.

7）Zhendong Song^#, Yi-You Huang^#, Ke-Qiang Hou^#, Lu Liu, Feng Zhou, Yue Huang, Guohui Wan, Hai-Bin Luo^*, Xiao-Feng Xiong^*. Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis. J. Med. Chem. 2022, 65: 4238-4254.

8）Jinhao Liang^#, Yi-You Huang^#, Qian Zhou^#, Yuqi Gao, Zhe Li, Deyan Wu, Si Yu, Lei Guo, Zhen Chen, Ling Huang, Steven H. Liang, Xixin He^*, Ruibo Wu^*, Hai-Bin Luo^*. Discovery and Optimization of α-Mangostin Derivatives as Novel PDE4 Inhibitors for the Treatment of Vascular Dementia. J. Med. Chem. 2020, 63: 3370-3380.

9）Zhe Li^#, Yi-You Huang ^#, Yinuo Wu, Jingyi Chen, Deyan Wu, Chang-Guo Zhan^*, Hai-Bin Luo^*. Absolute Binding Free Energy Calculation and Design of a Subnanomolar Inhibitor of Phosphodiesterase-10. J. Med. Chem. 2019, 62: 2099-2111.

10）Zhe Li^#, Xin Li^#, Yi-You Huang^#, Yaoxing Wu, Runduo Liu, Lingli Zhou, Yuxi Lin, Deyan Wu, Lei Zhang,Hao Liu, Ximing Xu, Kunqian Yu, Yuxia Zhang, Jun Cui^*, Chang-Guo Zhan^*, Xin Wang^*, Hai-Bin Luo^*. Identify Potent SARS-CoV-2 Main Protease Inhibitors via Accelerated Free Energy Perturbation-based Virtual Screening of Existing Drugs. Proc. Natl. Acad. Sci. USA .2020, 117: 27381-27387.

11）Yi-You Huang^#, Xin Liu^#, Deyan Wu, Guihua Tang, Zengwei Lai, Xuehua Zheng^*, Sheng Yin^*, Hai-Bin Luo^*. The Discovery, Complex Crystal Structure, and Recognition Mechanism of a Novel Natural PDE4 Inhibitor from Selaginella pulvinata. Biochem. Pharmacol. 2017, 130: 51-59.

12）Yi-You Huang, Zhe Li, Yinghong Cai, Lingjun Feng, Yinuo Wu, Xingshu Li, Hai-bin Luo^*. The Molecular Basis for the Selectivity of Tadalafil Toward Phosphodiesterase 5 and 6: a Modeling Study. J. Chem. Inf. Model. 2013, 53: 3044-3053.

13）Yan-Fa Yu^#, Chen Zhang^#, Yi-You Huang^#, Sirui Zhang, Qian Zhou, Xiangmin Li, Zengwei Lai, Zhe Li, Yuqi Gao, Yinuo Wu, Lei Guo^*, Deyan Wu^*, Hai-Bin Luo. Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors. ACS Chem. Neurosci. 2020, 11: 1058-1071.

14）Xiaoxia Qiu^#, Yiyou Huang^#, Deyan Wu, Fei Mao, Jin Zhu, Wenzhong Yan^*, Hai-bin Luo^*, Jian Li^*. Discovery of Novel Purine Nucleoside Derivatives as Phosphodiesterase 2 (PDE2) Inhibitors: Structure-based Virtual Screening, Optimization and Biological Evaluation. Bioorgan. Med. Chem. 2018, 26: 119-133.

15）Ting Yao^#, Yiyou Huang^#, Meng Zhang, Yujuan Chen, Hairun Pei, Jianyou Shi*, Huanchen Wang^*, Yousheng Wang^*, Hengming Ke^*. Crystal Structures of Candida Albicans Phosphodiesterase 2 and Implications for Its Biological Functions. Biochemistry, 2018, 57: 6070-6077.

16）Tingting Lin^#, Yiyou Huang^#, Guihua Tang, Zhongbin Cheng, Xin Liu, Hai-bin Luo^*, Sheng Yin^*. Prenylated Coumarins: Natural Phosphodiesterase-4 Inhibitors from Toddalia Asiatica. J. Nat. Prod. 2014, 77: 955-962.

17）Yena Liu^#, Yiyou Huang^#, Jingmei Bao, Yinghong Cai, Yanqiong Guo, Shaonan Liu, Hai-bin Luo^*, Sheng Yin^*. Natural Phosphodiesterase-4 (PDE4) Inhibitors from Crotalaria Ferruginea. Fitoterapia, 2014, 94: 177–182.

18）Jiasheng Zhong^#, Yiyou Huang^#, Wenjing Ding, Xiaofang Wu, Jinzhi Wan^*, Hai-bin Luo^*. Chemical Constituents of Aloe Barbadensis Miller and Their Inhibitory Effects on Phosphodiesterase-4D. Fitoterapia, 2013, 91: 159-165.

歡迎有藥學、生物學、化學等相關學科背景的同學報考本課題組的博士/碩士研究生。